Clinicians are set to take control of the NHS Budget, with the borough being one of three in London to pilot new health services provisions.
Wandsworth Clinical Commissioning Group (CCG) will be responsible for patients in the area from April 2013, replacing NHS South West London.
The group went through a rigorous process via the NHS Commissioning Board to ensure it could take on the role.
It is among 35 CCGs in the UK that have been approved in the first wave of the authorisation process. Islington and Kingston were the only other two groups in London to get the go ahead.
Graham Mackenzie, Wandsworth CCG chief officer, said: “We welcome this announcement and are proud to be one of the first CCGs to be authorised, however, we will not rest on our laurels and we view this as our first big step on our journey towards continuous improvement.
“Clinical commissioning allows health professionals the freedom to respond, innovate and develop services in the way that best meets the needs and wishes of residents.”
Dr Nicola Jones, clinical chairman, said: “We have formed our top priorities based on the needs of the diverse population of Wandsworth.”
The remaining 177 CCGs are set to be approved in a further three waves, with results to be published in January, February and March 2013.