Plans to redevelop Homebase in Swandon Way into a multi-level block of flats are back on the table with Wandsworth Council and hundreds of people have objected.
If granted, the current Homebase building would be knocked down and replaced with three buildings, one of which would be 17-storeys high, with a total of 321 homes.
A similar application was delayed in Spring, and renewed designs submitted to the planning committee at the council on May 16.
Designers Allies and Morrison cite benefits of the scheme as the creation of jobs, the addition of a northern entrance in Wandsworth Town station with a public square, and a playspace for children.
The tallest building is the station building, which has been redesigned with smaller corner balconies for a "slimmer silhouette" and light grey and cream brick piers to replace stone piers.
The two buildings next to it have been called the garden building and the crescent building.
The smallest building will be nine storeys.
Included in the application is provision for office space, retail units and a nursery, as well as 100 car parking spaces.
An objection letter from the Wandsworth Society states: "This site is not a town centre location where approved tall buildings have been located in commercial or mixed-use locations where their overbearing character has been held not to affect significant numbers of local residents.
"Here the tower will directly dominate the close knit, small-scale houses, flats and cottages in the Tonsleys.
"The scheme resembles nothing so much as a 1970s office development.
"We note also that the density of the scheme is well above the maximum density range for this location."
The society has also criticised the low level of affordable housing, with 23.6 per cent in the overall scheme and the capacity at Wandsworth Town station.
Mark Nelson, chairman of the Riverside West residents' association, wrote in to object, stating the height of buildings would impact sunlight and that blocking off Old York Road will affect the businesses.
His letter states: "The local area and public services are already congested, therefore creating even further properties would require additional investment into public services for the area of which no details have been provided.
"We must give consideration to the peak times of the working week, as the train station at Wandsworth Town is already beyond reasonable safe limits."
The application is due to go before Wandsworth Council's planning committee on June 27.